Sunifiram is one of the latest, cutting edge nootropics available in the market this year, one of a new class of nootropics called ‘ampakines’. Ampakines work to improve the functioning of the AMPA neurological receptor, which enables faster and clearer signal transmission speed across synapses. It also works to enhance long-term potentiation- the process by which we go about learning or remembering anything. My Sunifiram experience suggests that this new nootropic may help you learn things and recall them faster- giving you that margin of extra focus, creativity, productivity, and mental wakefulness without caffeine or amphetamines.
Nootropics are a wide class of chemicals which act in different ways to alter the availability of neurotransmitters, improve the oxygen supply in the brain, or stimulate nerve growth; which in turn supports the mind, memory and cognition. To qualify as being a nootropic, they also need to be shown as free of negative side-effects. Nootropics are actively being researched in laboratories as possible treatments for Alzheimer’s Disease, schizophrenia, or reversing depression, as well as the treatment of autism or dementia. Many people interested in personal betterment or higher levels of work and study performance use Nootropics as a way to get more focused, clear, and remember things faster. For me, I like the idea of getting smarter, and I like to experiment.
All the nootropics have given different results. Some work well when I would like to zone into a work project on a computer (oxiracetam and modafinil), while others enhance creativity, music, and color saturation (aniracetam). As I do a lot of teaching and training, I like to enhance verbal acuity which seems to be accentuated by using piracetam. For me. Not one has been the magic bullet that works in all contexts, day in and day out.
After trolling online forums and doing research for a few months I decided to give Sunifiram a try. Sunifiram is derivative of piracetam but many times stronger. A study on brain damaged rats published on Pubmed showed that “Sunifiram improves cognitive defects“, improves the functioning of both AMPA and NMDA neurological receptors, and exerts an influence on the hippocampus of the brain. The subjective reports of Sunifiram people were giving were quite interesting, and it had gotten a reputation as being “sunny” in quality.
I ordered 2 grams of pure 98% pure Sunifiram from LIFTMODE,and received it in a few days complete with a purity analysis and very small plastic spoon for measuring your dosage. While using a digital scale would be best, after my breakfast of yogurt and blueberries, I scooped what is supposed to be between 7-10 mg under my tongue. At first I wasn’t sure if it made it to my tongue as it’s such a small amount and a very light taste.
To put this dosage in perspective, I didn’t notice much effects from piracetam under 3,500 mg. At this amount you could be forgiven for not even knowing it was under your tongue. The effects came on quickly and were immediately pleasant. Within a few minutes of this micro dose, I experienced a kind of bright clarity coming over me- and colors became pleasantly and subtly brighter and warmer. My mood felt ‘sunny’ as the reports had suggested. Within the hour I met up with a friend and was happily chatting along, feeling unusually articulate – able to rapidly connect disparate ideas and seamlessly bring them into the tangents of conversation. I felt mentally fast yet amiable and pleasant. I did wonder if I was maybe a bit too talkative however.
Of course, these are highly subjective experiences that one could chalk up to a number of things- the caffeine from my coffee, nice weather, and catching up with a friend, but there was some added depth and clarity that felt new to me. Nonetheless, I decided to perform a few tests to see if I was just imagining things.
First test I used a friend who has no experience with nootropics as a test subject. I scooped out approximately the same amount, flipped it on his tongue and waited. Within minutes he transformed slightly- beginning to look increasingly alert and engaged. He looked a bit too enthusiastic. A few hours later he told me, ‘the words are flowing out effortlessly, it’s kind of like I had a brain enema’
For the second test, I dosed on Sunifiram again the next morning, and tested my ability with the ‘dual n-back game’ which is a free app that professionals use to assess something called ‘working memory’ and ‘fluid intelligence’. That’s not to say that Ampakines or specifically Sunifiram works on that part of the intelligence- I don’t know if it does or not, but this is an easily accessible way of checking how sharp you are, at least by one measure. Before Sunifiram I scored 53.7% average on 10 games of dual n-back, dosed another 7-10mg and then 2 hours later my score rose slightly to 59.3%. Does it prove anything? I’m not sure, maybe I got a little bit better through practice.
So far, Sunifiram is easily the one nootropic that I have personally experimented with that has strongly noticeable, immediate effects, both lifting my mood, brightening my visual scope, and enhancing my verbal skill. It seems to be particularly good to use just prior to situations where you will need to be impressive with your words and ideas. Keep in mind that Sunifiram is one of the newest Ampakines available and as such has no human clinical trials done on it as of yet, so some experimentation will be needed for you to find what and how much works for you and your individual chemistry.
UPDATE 23 July 2013
Since the positive initial effects of sunifiram, unfortunately they have not sustained themselves. Now when I take a dosage, even after a week of not taking any- I notice no changes at all, no effects from even smaller or larger dosages. Unclear as why this is. Examine.com suggests that a dosage of 5-11 milligrams may be appropriate for a human based on rat studies and that Sunifiram has an “N-shaped” dose curve, meaning that beyond a certain threshold, more does not equal stronger.
Do you have experience with Sunifiram DM-235? Please leave your comments and discussion!